Colorectal cancer cohort study (COLO-COHORT)

Study hypothesis: 1. It is possible to identify factors (derived from socio-demographics, medical history, family history, lifestyle, FIT test results, blood test results) which successfully predict risk of colorectal neoplasia in individuals with symptoms attending for colonoscopy
2. It is possible to identify those individuals most likely to have advanced adenomas (adenomas ≥10mm, any villous component, presence of high-grade dysplasia) or CRC at surveillance colonoscopy
3. Individuals with and without colorectal neoplasia have distinct microbiome profiles
4. To develop a platform of patients who consent to future contact for future research studies (COLO-SPEED)
Primary outcome(s): The occurrence of colorectal neoplasia (colorectal cancer and advanced adenomas), measured by reviewing patient endoscopy reports, blood results, and health questionnaire. These will be analysed via logistic regression and subsequent structural equation modelling. Timepoint: baseline