NUDT2 hydrolyses GP4G to GTP, GMP

Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2) mediates the asymmetrical hydrolysis of P(1),P(4)-bis(5'-guanosyl) tetraphosphate (GP4G) to yield AMP and ATP. GP4G is implicated in the regulation of cellular responses to stress and its hydrolysis could serve as a mechanism by which homeostasis is maintained by preventing its build-up (Thorne et al. 1995, Swarbrick et al. 2005).

双(5'-核苷)-四磷酸酶（非对称性）(NUDT2)介导P(1),P(4)-双(5'-鸟苷)四磷酸(GP4G)的非对称性水解，从而产生腺苷三磷酸(AMP)和腺苷酸三磷酸(ATP)。GP4G与细胞对压力反应的调控相关，其水解可能作为一种机制，通过防止其积累来维持稳态，相关研究可追溯至Thorne等人(1995年)、Swarbrick等人(2005年)的工作。