human leukemia cell line K562 offspring acquring imatinib resistance(K562-r) : Control vs. Drug treated

ChEBI2010-12-30 更新2026-07-21 收录

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human leukemia cell line K562 offspring acquring imatinib resistance(K562-r) : Control vs. Drug treated

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2010-12-30

Data

Transcriptomic Profiling Reveals Key Molecular Events and Pathways Driving Acquired Chemotherapy Resistance in Relapsed Acute Myeloid Leukemia

DataCite Commons2025-11-20 更新100

Supplementary Material for: Deoxycytidine Kinase ( DCK ) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine

Resistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded by DCK , catalyzes phosphorylation of cytarabine to

DataCite Commons2021-02-24 更新80

cFos Mediates cAMP-Dependent Generation of ROS and Rescue of Maturation Program in Retinoid-Resistant Acute Promyelocytic Leukemia Cell Line NB4-LR1

A determining role has been assigned to cAMP in the signaling pathways that relieve resistance to anti-leukemia differentiation therapy. However, the underlying mechanisms have not been elucidated yet

NIAID Data Ecosystem60

Genome-wide expression of the leukemic cells with different sensitivity to AraC. Mus musculus

To examine the molecular alterations in cells with different sensitivity, genome-wide expression of the leukemic cells was profiled, revealing that overall 366 and 212 genes became upregulated or down

NIAID Data Ecosystem80

Exosomes mediate intercellular transference of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia.

The interplay between cancer cells and microenvironment can influence treatment response and plays a key role in the emergence of drug resistance. Rapidly acquired resistance prevents proteasome inhib

NIAID Data Ecosystem60