Role of Caveolin 1 in metabolic programming of fetal brain (bulk RNA-seq data)

Caveolae are plasma membrane invaginations found in most cells of mammals. Caveolin-1 (Cav1) encodes a major protein of the lipid rafts of these membrane structures. Cav1-null mice, though viable, show various phenotypic defects. At an early adult age, these mice show brain aging that resemble brain of one and half year old wildtype mice, and exhibit symptoms that are hallmarks of Alzheimer’s disease. It is not known if the ablation of Cav1 in these mice impacts the brain at the fetal stage that then influences brain function later in life. RNA-seq was performed to profile gene expression of fetal brain (gestation day 15) and aging brain (week 70) of Cav1 knockout mice. The data was comapred with genes expression data of fetal brain (gestation day 15) and aging brain (week 70) of wildtype mice from our earlier study. RNA-seq was performed with fetal brain (gestation day 15) of wild-type and Cav1 knockout mice. Aging brain (week 70) from Cav1 knockout mice was also sequenced and compared with RNA-seq data of WT mice generated from our earlier study.