Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial striatal cognitive processing during interval timing, an elementary cognitive task that requires mice to estimate intervals of several seconds and involves working memory for temporal rules as well as attention to the passage of time. We harnessed optogenetic tagging to record from striatal D2- dopamine receptor-expressing medium spiny neurons (D2-MSNs) in the indirect pathway and from D1-dopamine receptor-expressing MSNs (D1-MSNs) in the direct pathway. We found that D2-MSNs and D1-MSNs exhibited distinct dynamics over temporal intervals as quantified by principal component analyses and trial-by-trial generalized linear models. MSN recordings helped construct and constrain a four-parameter drift-diffusion computational model in which MSN ensemble activity represented the accumulation of temporal evidence. This model predicted that disrupting either D2-MSNs or D1-MSNs would increase interval timing..., This dataset contains raw data collected using MedAssociates and OpenEphys, and sorted using Plexon's Offline Sorter.
Raw MedAssociates Files and Plexon files are shared.
Loading code in MATLAB along with code to plot figures is included. 
Note the while code is available on GitHub: https://github.com/nandakumar-narayanan/https-elifesciences.org-reviewed-preprints-96287eLife/   code is also included in this repository as well as on our website: https://bit.ly/CogStriatum, , \#This README file was generated in March 2025 by Nandakumar Narayanan

# General information

## Dataset Title

Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

[https://doi.org/10.5061/dryad.g4f4qrg15](https://doi.org/10.5061/dryad.g4f4qrg15)

## Date of Data Collection

2021-2024

## Contributors

* Nandakumar Narayanan, University of Iowa

## Overview

DOI: 10.5061/dryad.g4f4qrg15

Paper Link: [https://doi.org/10.7554/eLife.96287](https://doi.org/10.7554/eLife.96287)

This is a complex behavioral, modeling, and neurophysiological dataset that captures how mouse dorsomedial striatal D2-MSNs and D1-MSNs represent time.  The data are involve mouse optogenetic tagging, computational modeling, mouse optogenetic behavior, and combined neurophysiology and pharmacology.

The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial striatal cognitive processing during interval timing, an elementary cognitive task that requires mice to ...,