Complex organisms are able to rapidly induce select genes among thousands in response to diverse environmental cues. This occurs in the context of large genomes condensed with histone proteins into ch
Infection of macrophages by Salmonella induces a transcriptional inflammatory response. The pattern of Salmonella induced genes is significantly altered by the expression of type I interferons. We use
Recent studies suggest that PDEF is required for secretory cell differentiation in several epithelial tissues. To investigate PDEF in the mammary gland, we examined the effect of this transcription fa
In order to understand the gene expression pathways affected by inflammation through interferon gamma, total RNA was extracted from human CD34+ cells with and without interferon gamma exposure for 48
The presence of oxidized DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and apurinic/apyrimidinic sites (AP sites), has been described as epigenetic signals that are involved in gene expressio