Top2a

ENCODES a protein that exhibits ATP binding; chromatin binding; DNA binding; INVOLVED IN cerebellar granule cell differentiation; cerebellar Purkinje cell differentiation; DNA topological change; PARTICIPATES IN doxorubicin pharmacodynamics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); FOUND IN DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; centriole (ortholog); chromosome, centromeric region (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol

编码一种表现出ATP结合、染色质结合、DNA结合特性的蛋白质；参与小脑颗粒细胞分化、小脑浦肯野细胞分化、DNA拓扑结构改变；参与阿霉素药代动力学途径、依托泊苷药代动力学途径；与小脑颗粒细胞分化（同源）、腺样囊性癌（同源）、肾上腺皮质癌（同源）相关；存在于DNA拓扑异构酶II型（双链切割、ATP水解）复合物中、中心粒（同源）、染色体着丝粒区域（同源）中；与1-萘基异硫氰酸酯、17α-乙炔基雌二醇、17β-雌二醇相互作用。