p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a sear

PubMed Central1996-10-01 更新30

A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane. A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane

乳腺癌激素治疗

受体信号传导

This work show that hormone action, which is assumed to act via binding to intracellular nuclear receptors, can also trigger a global cellular response acting on membrane bound receptors. We designed

NIAID Data Ecosystem30

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

调节性T细胞功能

自身免疫疾病机制

BackgroundCD4+CD25+FOXP3+ Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in

NIAID Data Ecosystem40

The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

受体信号传导

乳腺癌药理学

The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whethe

PubMed Central1993-05-15 更新30

Continuous requirement for the T cell receptor for regulatory T cell function

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