Genotype-Phenotype Interactions for TLR4 and NOD2 Genotypes and Plasma Inflammatory Markers, among Women with a History of Early-Onset Preeclampsia and Controls with Only Uneventful Pregnancies *

*Data represent odds ratios and 95% CIs for early-onset preeclampsia compared to controls with at least one uneventful pregnancy, with respect to the reference group (R) of women negative for the all minor allelic variants of TLR4 and NOD2 and with low values for plasma inflammatory markers. High values are values within the highest tertiles of the distribution of plasma levels of the control group. Low values are values within the lowest tertiles (reference group) and values within the lower two tertiles (TLR4 and NOD2 positive group), respectively; CRP denotes C-reactive protein, IL-6 interleukin-6, sICAM soluble intercellular adhesion molecule-1 and vWf von Willebrand factor.†P values for trend between groups, compared to the reference group (R) of women negative for allelic variants of TLR4 and NOD2, and with low levels of plasma inflammatory markers, by univariable logistic regression analysis.¶Pa values for trend between groups, compared to the reference group (R), after adjustment for age at inclusion, interval between delivery and enrolment, body-mass index, smoking and chronic hypertension, by multivariable logistic regression analysis.