MULTIDIMENSIONAL EVALUATION OF EPIDEMIOLOGY, PATHOGENESIS, AND CLINICO-MORPHOLOGICAL ASPECTS OF CHRONIC DIFFUSE LIVER PATHOLOGY

The present study substantiates the worldwide clinical and public health relevance of chronic diffuse liver diseases (CDLD). The leading etiological contributors are identified as metabolic dysfunction-associated fatty liver disease (MAFLD/MASH), chronic viral hepatitis B and C, and alcohol-related liver injury. MAFLD demonstrates a notably high global prevalence (around 30%), with a marked upward trend over the last decade, reaching pandemic proportions. Chronic HBV and HCV infections are discussed in terms of their persistence rates and well-established potential to evolve into cirrhosis and hepatocellular carcinoma, particularly in cases of vertical HBV transmission.