Raw and analyzed data_Soll et al 2021

In this study we used the SOD1 G93R mutant zebrafish ALS model to assess whether <b>1-Fe</b>, as a potent catalytic antioxidant<b>,</b> displays any therapeutic merits in vivo. Our results show that <b>1-Fe</b> caused a substantial increase in mutant zebrafish locomotor activity (up to 30%), bringing the locomotive abilities of the mutant treated group close to that of the wild type untreated group (50% more than the mutated untreated group). Furthermore, <b>1-Fe</b> did not affect WT larvae locomotor activity, suggesting that <b>1-Fe</b> enhances locomotor ability by targeting mechanisms underlying SOD1 ALS specifically. These results may pave the way for future development of <b>1-Fe </b>as a viable treatment for ALS.