BIOGRID CURATED DATA FOR SEL-12 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for SEL-12 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.

蛋白质-蛋白质、遗传和化学相互作用数据集，针对 Caenorhabditis elegans 中的 SEL-12（由 BioGRID 精心整理，详见 https://thebiogrid.org）；定义：SEL-12 基因编码一种跨膜结构域蛋白，与前体蛋白（presenilins）同源；在生殖腺、生殖细胞和腹面发育过程中，SEL-12 在接收细胞内发挥功能，以正向调控 lin-12 和 glp-1 类 Notch 信号通路；SEL-12 的前体蛋白活性和/或水平可能受到由 spr-2 编码的 SET/NAP 蛋白亚家族成员的调控，因为 sel-12 的突变可被 spr-2 的突变所抑制；spr-2 对 sel-12 的调控以 hop-1 前体蛋白依赖的方式进行。