Genomic Analysis of the Genotype-Phenotype Map in the model organism Drosophila

The overall goal is to develop an intellectual framework for illuminating the path from genotype to phenotype, and for predicting the latter from the former. Three broad questions related to this problem: 1) How to infer mechanisms by which genetic variation leads to changes in phenotype? 2) How to improve the design, understanding and interpretation of association studies by exploiting prior information? 3) How to identify general principles about the genotype-phenotype map? These questions will be addressed through a series of interrelated projects that combine computational and experimental methods, explored in Drosophila, and involve a wide range of researchers including molecular biologists, population geneticists, genetic epidemiologists, statisticians, computer scientists, and mathematicians.