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The expression of a subset of P2X receptors is modulated after OGD.

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P2X receptor subunit expression in neuroblasts during OGD was analyzed in organotypic cultures at 10 DIV. Slices were subjected to 30 min OGD in the presence or absence of PPADS and fixed 24 hours later. Co-expression of DCX with P2X receptor subunits was assessed by confocal analysis both in the SVZ and in the cortex under different experimental conditions. Abbreviations: CTRL, control consisting of 1 mg/ml glucose; OGD, oxygen and glucose deprivation; OGD/PPADS, OGD in the presence of 100 µM PPADS.

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2009-04-23
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