Sier2017_estrogen_PBPK_GSMN

Physiologically-based Pharmacokinetic (PBPK) model of estradiol disposition in humans. Based on Sier et al_2017_estrogen PBPK_simple (MODEL1711210001), but with intrinsic (i.e. liver-mediated) clearance term replaced by a genome scale metabolic network. Extrahepatic clearance is still represented by as simple mass action Model was developed in the Multi-Formalism Interaction Network Simulator (MuFINS), as described in Wu et al 2017 (doi: 10.1038/npjsba.2016.32). relevant Software and tutorials can be found at http://sysbio3.fhms.surrey.ac.uk/mufins/