G alpha (q) binds to Trio family RhoGEFs

The Trio family of RhoA guanine nucleotide exchange factors (RhoGEFs) are directly activated by G alpha (q), possibly within a Gq:Trio:RhoA signalling complex, thereby linking Gq to RhoA-mediated processes such as cell migration, proliferation, and contraction. Like most other RhoGEFs, they have a tandem motif consisting of a Dbl homology (DH) and a pleckstrin homology (PH) domain. Trio and Duet have a number of other domains including an immunoglobin domains that may be involved in interacting with Rho, but the considerably smaller GEFT (p63RhoGEF) does not have any identifiable additional domains yet appears to be sufficient to mediate the activation of RhoA by G alpha (q). The structure represented by GEFT is proposed to represent the core of an ancient signal transduction pathway.

Trio家族的RhoA鸟苷酸交换因子（RhoGEFs）直接被G alpha (q)激活，可能是在Gq:Trio:RhoA信号复合物内，从而将Gq与RhoA介导的过程如细胞迁移、增殖和收缩联系起来。与大多数其他RhoGEFs类似，它们具有由Dbl同源（DH）和pleckstrin同源（PH）结构域组成的串联基序。Trio和Duet含有多个其他结构域，包括可能与Rho相互作用的免疫球蛋白结构域，但相对较小的GEFT（p63RhoGEF）尚未识别出任何额外的结构域，却似乎足以介导G alpha (q)激活RhoA。由GEFT所代表的结构被提议代表一条古老信号传导途径的核心。