Raw data PONE-D-24–43444.

BackgroundTuberculosis (TB) substantially compromises health-related quality of life (HRQoL), yet limited studies have assessed its impact on Ethiopian patients using the EQ-5D instrument. This study evaluates HRQoL, estimates health state utility values, and identifies associated factors among TB patients in Ethiopia.MethodsA cross-sectional study was conducted across 20 public health centers in Addis Ababa, Ethiopia, involving 672 TB patients selected via proportional allocation. HRQoL was measured using the EuroQol five-dimension five-level (EQ-5D-5L) tool. Predictors of utility scores were analyzed using the Kruskal-Wallis test and Tobit censored regression models.ResultsAnxiety/depression was the most frequently affected dimension (55.4% of participants). The mean EQ-5D-5L utility score was 0.91 (SD ± 0.14), and the mean EQ-VAS score was 80.6 (SD ± 15.6). Older age (55–64 years: β = −0.067, p p p p p p = 0.011) correlated with better HRQoL.ConclusionThe findings underscore the influence of socio-demographic and clinical factors on HRQoL among TB patients in Ethiopia, calling for targeted interventions and policy reforms to enhance treatment outcomes and patient support.