Table S4. Top pathways and pathway-smoking interactions that are associated with lung squamous cell carcinoma. from A Novel Pathway-Based Approach Improves Lung Cancer Risk Prediction Using Germline Genetic Variations

For individuals in the EAGLE study, all consisting of Italians, a pathway-level susceptibility effect was computed for each pathway in MSigDB as the sum of relevant SNP variant alleles weighted by their log odds ratios from the TRICL lung squamous cell carcinoma GWAS meta-analysis. Pathway values were also multiplied by cumulative smoking pack-years to produce pathway-smoking interactions. The pathways and pathway-smoking interactions that differ most between lung squamous cell carcinoma cases and healthy controls (t-test P < 0.05) in the EAGLE study are presented. Pearson correlation coefficients between these pathways and pathway-smoking interactions, and each of age, sex, and smoking pack-years are presented as well.