Intracellular dNTP levels impact prime editing efficiency. Homo sapiens
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1024467
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资源简介：
In primary cell types, intracellular dNTP levels are tightly regulated in a cell cycle dependent manner. We report that prime editing efficiency is increased by mutations that improve the enzymatic properties of MMLV-reverse transcriptase and treatments that increase intracellular dNTP levels. In combination, these modifications produce substantial increases in precise editing rates.
创建时间：
2023-10-05
