Datasets used in generating Figure 7 of Button et al., 2025 The 1 –Cys peroxiredoxin, PRDX-6, suppresses an NHR-49-dependent pro-survival response, including the Flavin monoxygenase, FMO-2, that protects against fungal and bacterial infection.

Datasets used to generate panels in Figure 7: NHR-49 is required for induction of fmo-2 in response to C. albicans leading us to propose that NHR-49 mediates the effect of loss of prdx-6 on fmo-2 expression an stress resistance and innate immunity in Button et al. 2025 https://doi.org/10.1016/j.redox.2025.103992
Figure 7A: Excel file containing analysis of the intestinal expression of the fmo-2P::gfp reporter gene in wild-type and nhr-49 (nr2041) mutant C. elegans before and following 18h C. albicans exposure. This dataset is representative of multiple independent experiments involving at least 20 animals in each group.
Figure 7C: Excel file containing analysis of the survival of L4 stage wild-type, prdx-6(tm4225), fmo-2(ok2147) and prdx-6(tm4225) fmo-2(ok2147) mutant animals following transfer to plates containing 5mM sodium arsenite. This dataset is representative of multiple independent experiments involving at least 40 animals in each group.
Figure 7D: Excel file containing analysis of the survival of L4 stage wild-type (N2), prdx-6(tm4225), fmo-2(ok2147) and prdx-6(tm4225) fmo-2(ok2147) mutant animals at 15oC. This dataset is representative of multiple independent experiments carried out in the presence of FUDR.
Figure 7E: Excel file containing analysis of the survival of L4 stage wild-type, prdx-6(tm4225), fmo-2(ok2147) and prdx-6(tm4225) fmo-2(ok2147) mutant animals following infection with Staphylococcus aureus. This dataset is representative of multiple independent experiments.
Figure 7F: Excel file containing analysis of the number of viable or unhatched eggs laid by wild-type (N2), prdx-6(tm4225), nhr-49(nr2041) and prdx-6(tm4225) nhr-49(nr2041) mutant C. elegans maintained on NGM-L plates on NGM-L plates containing 0.8mM oleate. This dataset is representative of two independent experiments.
These are part of collection https://doi.org/10.25405/data.ncl.c.8231413