five

Regioselective Synthesis of Functionalized Dihydropyrones via the Petasis Reaction

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https://figshare.com/articles/dataset/Regioselective_Synthesis_of_Functionalized_Dihydropyrones_via_the_Petasis_Reaction/11461419
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资源简介:
A novel synthesis methodology for the construction of functionalized dihydropyrones has been developed with amines, glyoxylic acid, and 4-substituted-1,2-oxaborol-2­(5H)-ols from the Petasis reaction. Mechanistic investigation indicated the intermolecular SN2 cyclization to provide 3,6-dihydro-2H-pyran-2-ones (3,6-DHP) and 5,6-dihydro-2H-pyran-2-ones (5,6-DHP) in one step with moderate to excellent yields.
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2019-12-19
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