Significant and suggestive QTL for plasma esterified and free cholesterol in F2 mice derived from B6.apoE−/− and C3H.apoE−/− mice.

aFrom Mouse Genome Informatics database at http://www.informatics.jax.org.bSuggestive QTL and significant QTL were 2.4 and 3.4, respectively, for free cholesterol and 2.4 and 3.3, respectively, for esterified cholesterol as defined by 1000 permutation tests.cSupport intervals (SI) were defined by a 1-unit decrease in LOD score on either side of the peak marker.dVariance (%) indicates the percentage of the phenotypic variance at the peak marker.ePemp, empirically determined P-value for the whole genome, was calculated using the permutation test function of MapManager QTXb20.fModel of inheritance was determined using the MapManager QT program. C3H was the high allele at all the markers, contributing to elevated free or esterified cholesterol levels.