HVN COMFORT Metadata Record - The Christchurch IBS cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT)

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.<b>Description</b>: This cross-sectional observational case-control study was initiated in July 2016 with the aim of increasing an understanding of the underlying disease mechanisms in functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional diarrhoea (FD), and functional constipation (FC). Specific areas of interest include the effect of food, microbiome, host and microbial genetics, metabolome, and psychological variables on unexplained chronic gastrointestinal (GI) symptoms.Demographic, symptom, psychological, dietary, and health data were collected from 349 enrolled participants in addition to biological samples (breath, faeces, blood and urine). Colonic biopsies were taken at the time of colonoscopy from participants in the colonoscopy subgroup (n=220).

本元数据记录及其附带文件阐述了本研究收集的各类数据相关信息，并明确了该数据当前及未来的治理政策。<b>研究概况</b>：本横断面观察性病例对照研究于2016年7月启动，旨在加深对功能性胃肠病（functional gastrointestinal disorders, FGIDs）潜在发病机制的理解，此类疾病涵盖肠易激综合征（irritable bowel syndrome, IBS）、功能性腹泻（functional diarrhoea, FD）及功能性便秘（functional constipation, FC）。研究关注的特定领域包括饮食、微生物组（microbiome）、宿主与微生物遗传学、代谢组（metabolome）以及心理变量对不明原因慢性胃肠道（gastrointestinal, GI）症状的影响。本研究从349名入组参与者中收集了人口统计学、症状学、心理学、膳食及健康相关数据，同时采集了生物样本（呼气样本、粪便样本、血液样本与尿液样本）。对于结肠镜检查（colonoscopy）亚组（n=220）的参与者，在结肠镜检查期间采集了结肠活检组织。