Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

NIAID Data Ecosystem2026-05-02 收录

干细胞胰岛分化

单细胞多组学调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE202500 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2025-08-20

RFX3 is essential for the generation of functional human pancreatic islets from stem cells (1)

干细胞胰岛分化

RNA测序

Wild type iPSCs (WT-iPSCs) generated and fully characterized in our laboratory were used for RFX3 knockout iPSCs (RFX3 KO iPSCs) generation. WT-iPSCs and RFX3 KO iPSCs were differentiated into pancrea

NIAID Data Ecosystem90

Single nuclei multiomics of human stem cell-derived islets identifies deficiencies in lineage specification. Single nuclei multiomics of human stem cell-derived islets identifies deficiencies in lineage specification

干细胞胰岛分化

单核多组学

We profiled the transcritpome and ATAC profiles of human pancreatic islets generated from pluripotent stem cells. Multiomic profiling was also performed on primary human islets and in vivo matured SC-

NIAID Data Ecosystem60

Chromatin dynamics reveal circadian control of human in vitro islet maturation [ATAC-seq]

干细胞胰岛分化

昼夜节律代谢

Stem cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human stem cells differentiate into pancreatic isle

NIAID Data Ecosystem60

Chromatin dynamics reveal circadian control of human in vitro islet maturation [RNA-seq]

干细胞胰岛分化

昼夜节律代谢

NIAID Data Ecosystem60

Chromatin dynamics reveal circadian control of human in vitro islet maturation [WGBS]. Chromatin dynamics reveal circadian control of human in vitro islet maturation [WGBS]

干细胞胰岛分化

昼夜节律表观遗传调控

NIAID Data Ecosystem60