Advanced in vitro hemocompatibility assessment of biomaterials using a new flow incubation system
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We present a new setup that enables standardized whole blood incubation of biomedical materials under flow. A blood volume of 2 ml is recirculated over test surfaces in a custom-made parallel plate incubation system to determine the activation of hemostasis and inflammation. Controlled physiological shear rates between 125 s<sup>-1</sup> and 1,250 s<sup>-1</sup> and minimized contact to air are combined with a natural-like pumping process. A unique feature of this setup allows tracing adhesion of blood cells to test surfaces microscopically <em>in situ</em>. Validation testing was performed in comparison to previously applied whole blood incubation methodologies.
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Zenodo创建时间：
2023-07-12
