SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

SEPT7 forms a ternary complex with MAPK6 and MAPKAPK5 that contributes to neuronal development through the phosphorylation of the Binders of RHO GTPase (BORG) proteins (Brand et al, 2012). Septins are cytoskeletal GTP-binding proteins that form filaments and contribute to processes such as cytokinesis, cell polarity and cell division, among others (reviewed in Spiliotis and Nelson, 2006). Interaction of septin proteins with the CDC42 effector proteins 2, 3 and 5 (CDC42EP2, 3, 5; also known as BORG1, 2 and 3) inhibits formation of septin filaments (Jouberty et al, 2001).

SEPT7与MAPK6和MAPKAPK5形成三聚体复合物，通过磷酸化RHO GTPase（BORG）蛋白的结合蛋白（Brand等，2012年）在神经元发育中发挥作用。节茨蛋白是细胞骨架的GTP结合蛋白，能够形成纤维并参与细胞分裂、细胞极性和细胞分裂等过程（Spiliotis和Nelson，2006年综述）。节茨蛋白与CDC42效应蛋白2、3和5（CDC42EP2、3、5；亦称BORG1、2和3）的相互作用抑制了节茨蛋白纤维的形成（Jouberty等，2001年）。