Prioritized genes for Osteoarthritis loci.

Biological and database evidence was collected to identify the causal gene in each investigated osteoarthritis associated locus. Locus gene sets were constructed by taking a region of 500 Kb upstream and 500Kb downstream of the lead SNP of that locus (1MB locus region), in total we analyzed 152 genes. The table summarizes the biological evidence for each osteoarthritis associated locus: 1) Nearest located genes; 2) DEPICT gene prioritization results, only genes that were significantly prioritized (FDR http://www.informatics.jax.org/); 6) Human cartilage tissue gene expression; 7) differential gene expression between OA-lesioned cartilage tissue and non-lesioned cartilage tissue [19]; 8) OMIM phenotype; 9) eQTL evidence [20]; 10) Nonsynonymous variants in LD >0.6 with lead SNP. All evidence for each gene is summarized, genes with the highest number of different types of evidence are reported.