Heart and Vascular Health Study (HVH)

Objectives The Heart and Vascular Health Study (HVH) is a case-control study of risk factors for the development of myocardial infarction (MI), stroke, venous thrombosis (VT), and atrial fibrillation (AF). The study setting is Group Health, an integrated health care delivery system in Washington State. Background The HVH originated in 1988 with the examination of risk factors for MI. Over the ensuing years, the study has been funded by a series of grants, which have added case subjects with stroke, VT, and AF, and used a common control group. Study aims have focused on the associations of medication use with cardiovascular events. Starting in 1997, the study aims expanded to include genetic associations with cardiovascular disease. Participants recruited in 2009 or later and who provided blood samples for genetic analysis were asked for consent to deposit genetic and phenotype data in dbGaP. Design As part of the HVH study, case subjects were identified by searching for ICD-9 codes consistent with MI, stroke, VT, or AF, and medical records were reviewed to confirm the diagnosis. Control subjects were identified at random from the Group Health enrollment and were matched to MI cases. All subjects have an index date. For cases, the index date was assigned as the date that the cardiovascular event (MI, stroke, VT, or AF) came to clinical attention. For controls, the index date was a random date within the range of the case index dates. For both cases and controls, information was collected from the inpatient and outpatient medical record, by telephone interview with consenting survivors, and from the Group Health pharmacy and laboratory databases. Consenting participants provided a blood specimen. Genetic Research Genetic factors underlying cardiovascular disease are studied using DNA isolated from the blood samples.]]>
Heart and Vascular Health (HVH) Study dbGaP Acknowledgment StatementConsent to take part in research: The Heart and Vascular Health StudyHeart and Vascular Health Study Phenotype dataMANUAL OF OPERATIONSHeart and Vascular Health Study Study DescriptionMI Hypertensive men and women aged 30-79 were eligible to be included in this dataset from the MI case-control study if they experienced a non-fatal hospitalized MI between January 2006 and December 2009. Non-hypertensive women aged 30-79 who were peri- or post-menopausal at the time of the MI were eligible for inclusion in this dataset if they experienced a non-fatal hospitalized MI between January 2006 and June 2007. Potential MI cases were identified from hospital discharge diagnosis codes, and the MI diagnosis was confirmed by review of medical records. MIs that were a complication of surgery or a procedure were excluded. Only incident MI cases were included; MI cases with a prior MI were ineligible for the study. Stroke Hypertensive men and women aged 30-79 were eligible to be included in this dataset from the stroke case-control study if they experienced a non-fatal hospitalized stroke between January 2006 and December 2009. Non-hypertensive women aged 30-79 who were peri- or post-menopausal at the time of the stroke were eligible for inclusion in this dataset if they experienced a non-fatal hospitalized stroke between January 2006 and June 2007. Potential stroke cases were identified from hospital discharge diagnosis codes, and the stroke diagnosis and stroke subtype were confirmed by review of medical records. Only incident stroke cases were included; stroke cases with a prior stroke were ineligible for the study. VT VT includes both deep venous thrombosis (DVT) and pulmonary embolism (PE). Women aged 18-89 were eligible to be included in this dataset from the VT case-control study if they experienced a DVT and/or PE between January 2002 and December 2010. Men aged 30-89 were eligible to be included in this dataset if they experienced a DVT and/or PE between January 2002 and December 2011. Potential VT cases diagnosed in both inpatient and outpatient settings were identified using hospital discharge diagnosis codes and urgent care diagnosis codes. Additionally, subjects who received a prescription for low molecular weight heparin were screened as potential cases of DVT. We verified the diagnoses of DVT and/or PE and their dates of onset using information from the inpatient and outpatient medical records. Only incident VT cases were included; VT cases with a prior VT were ineligible for inclusion in this dataset. Early Onset AF Early onset AF is defined as AF first recognized at ages 30-65 in a person with no known heart disease, and includes both AF and atrial flutter. The AF study identified early onset AF cases with a date of clinically recognized AF onset between January 2005 and June 2007. First-time episodes of AF diagnosed in inpatient and outpatient settings were included. AF and its date of onset were verified by review of the inpatient and outpatient medical records. First-time episodes of AF that occurred during or after a surgical procedure and had resolved by the time of hospital discharge were not included. However, if a person had surgery-related AF that resolved, and later in time had AF that occurred in the absence of surgery, that second event was eligible as a first lifetime episode of non-surgery-related AF. If the onset of AF was recognized in a subject who already had clinically recognized heart disease, including heart failure, myocardial infarction, probable or definite angina, coronary bypass, coronary angioplasty, moderate or severe valvular heart disease, severe left ventricular hypertrophy, congenital heart disease, implanted pacemaker/AICD, or poor left ventricular systolic function, the AF case was not included. If a diagnosis of hyperthyroidism, pneumonia, active alcoholism, or another specific condition was identified as precipitating the AF, the AF case was not included. Controls Control subjects were a random sample of Group Health members frequency matched on age (by decade), sex, hypertension status, and calendar year of identification to the MI cases, the largest case group of the HVH study.]]>
1988 - Study originates 1997 - Study aims to expand to include genetic associations with cardiovascular disease 2009 - Participants who provided blood samples for genetic analysis are asked for consent to deposit genetic and phenotype data in dbGaP ]]>