Pharmacokinetic parameters of 4R in male rats. Rats received 6 mg/kg of 4R by either i.v., i.m. or s.c. routes. 4R levels were measured in plasma and brain samples at different time points. Values represent the mean ± SD. N = 3 rats for i.v. and s.c. and N = 6 for i.m.

t½, elimination half-life; Tmax, time to maximum plasma concentration; AUCinf, area under the plasma concentration-time curve extrapolated to infinity and Cmax, maximal plasma and brain concentration; F (%), bioavailability.
Pharmacokinetic parameters of 4R in male rats. Rats received 6 mg/kg of 4R by either i.v., i.m. or s.c. routes. 4R levels were measured in plasma and brain samples at different time points. Values represent the mean ± SD. N = 3 rats for i.v. and s.c. and N = 6 for i.m.