Microarray profiling of rats treated for 21 days with Lithium chloride (0.2% in chow), Lamotrigine (30 mg/kg), or appropriately matched vehicles

SD rats were dosed with gold mood stabilizer therapies, lithium or lamotrigine, at doses aimed at achieving therapeutically relevant drug exposures. Tissues were collected after 21 days of delivery to examine the impact of this treatment on gene expression in frontal cortex, hippocampus and striatum.本研究以SD大鼠为实验对象，施以金制剂情绪稳定剂、锂盐或拉莫三嗪进行干预，给药剂量旨在达到具有治疗相关性的药物暴露水平。给药21天后采集组织样本，以探究该治疗方案对前额皮层、海马体与纹状体中基因表达的影响。