articles 02.csv

File contains manuscripts/abstracts to be uploaded to Rayyan without duplicates.

Abstract: The growing demand for more efficient materials for medical applications  brought together two previously distinct fields: medicine and  engineering. Regenerative medicine has evolved with the engineering  contributions to improve materials and devices for medical use. In this  regard, graphene is one of the most promising materials for bone tissue  engineering and its potential for bone repair has been studied by  several research groups. The aim of this study is to conduct a scoping  review including articles published in the last 12 years (from 2010 to  2022) that have used graphene and its derivatives (graphene oxide and  reduced graphene) in preclinical studies for bone tissue regeneration,  searching in PubMed/MEDLINE, Embase, Web of Science, Cochrane Central,  and clinicaltrials.gov (to confirm no study has started with clinical trial). Boolean searches were performed using the defined key words “bone” and “graphene”,  and manuscript abstracts were uploaded to Rayyan, a web-tool for  systematic and scoping reviews. This scoping review was conducted based  on Joanna Briggs Institute Manual for Scoping Reviews and the report  follows the recommendations of the Preferred Reporting Items for  Systematic Reviews and Meta-Analyses – Extension for Scoping Reviews (PRISMA-ScR)  statement. After the search protocol and application of the inclusion  criteria, 77 studies were selected and evaluated by five blinded  researchers. Most of the selected studies used composite materials  associated with graphene and its derivatives to natural and synthetic  polymers, bioglass, and others. Although a variety of graphene materials  were analyzed in these studies, they all concluded that graphene, its  derivatives, and its composites improve bone repair processes by  increasing osteoconductivity, osteoinductivity, new bone formation, and  angiogenesis. Thus, this systematic review opens up new opportunities  for the development of novel strategies for bone tissue engineering with  graphene.