BRG1 bromodomain in complex with VBC via compound 17
收藏Protein Data Bank Japan2024-02-07 更新2026-04-19 收录
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BRG1 bromodomain in complex with VBC via compound 17 Descriptor: (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, CHLORIDE ION, Elongin-B, ... Authors: Kerry, P.S, Hole, A.J, Perez-Dorado, J.I. Deposit date: 2023-09-13 Release date: 2024-01-17 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.17 Å) Cite: PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models. J.Med.Chem., 67, 2024
创建时间：
2023-09-13
