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IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

ChEBI2013-04-23 更新2026-07-21 收录

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I型干扰素

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-41355 数据链接链接失效反馈

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IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

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创建时间：

2013-04-23

多能干细胞分化

I型干扰素

Upon virus infection,pluripotent stem cells neither induce nor respond to canonical Type I interferons (IFN-I). To better understand this biology,we characterized induced pluripotent stem cells (iPSCs

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Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

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炎症与表观遗传调控

Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of h

NIAID Data Ecosystem60

Inherited human IRAK-1 deficiency selectively abolishes TLR signaling in fibroblasts

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免疫表型

We describe here a male infant with a 100 kb de novo Xq28 deletion encompassing parts of the TMEM187 and MECP2 protein-coding genes and the IRAK1 protein-coding gene, as well as the MIR3202-1, MIR3202

NIAID Data Ecosystem50

Loss of prion protein induces a primed state of type I interferon-responsive genes

朊蛋白免疫调节

I型干扰素

The cellular prion protein (PrPC) has been extensively studied because of its pivotal role in prion diseases; however, its functions remain incompletely understood. A unique line of goats has been ide

NIAID Data Ecosystem70

Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways

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细胞基因调控

Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure

NIAID Data Ecosystem50

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

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