Treponema pallidum isolate:X-4 Genome sequencing

The overlap among human pathogenic treponemas in transmission and clinical manifestations reminds us need to be careful to characteristic a isolate with a novel or unusual molecular sequence-type. Recently, we identified a novel tp0548 subtype from a patient X-4 who attended the outpatient department of Zhongshan Hospital, Xiamen University for indurated painful genital ulceration. Out of careful consideration, we conduct further molecular analysis in genome-scale to fully characterize the isolate and determine whether the infection agent of the X-4 isolate was a novel TPA strain or other treponemas which was misdiagnosed clinically.