Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA

Conclusions: Results suggest that (1) methylone is a rapid-acting neuroplastogen that affects key brain substrates for PTSD and MDD and that (2) methylone appears to exhibit higher specificity and fewer off-target effects than MDMA. Together, these results are consistent with the reported clinical experiences of methylone and MDMA and bolster the potential use of methylone in the treatment of PTSD and, potentially, other neuropsychiatric disorders.结论：研究结果显示：(1) 甲氧麻黄酮（Methylone）是一种快速起效的神经可塑性调节剂（neuroplastogen），可靶向影响与创伤后应激障碍（Post-Traumatic Stress Disorder, PTSD）及重度抑郁症（Major Depressive Disorder, MDD）相关的关键脑底物；(2) 相较于3,4-亚甲二氧甲基苯丙胺（MDMA），甲氧麻黄酮具备更高的特异性与更少的脱靶效应。综上，上述研究结果与甲氧麻黄酮和MDMA已报道的临床应用经验一致，同时为甲氧麻黄酮用于创伤后应激障碍乃至其他神经精神疾病的治疗提供了支撑。