Crystal structure of hCA II in complex with 1-Aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide inhibitor

Crystal structure of hCA II in complex with 1-Aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide inhibitor Descriptor: (1~{S})-6,7-dimethoxy-1-phenyl-3,4-dihydro-1~{H}-isoquinoline-2-sulfonamide, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ... Authors: Di Fiore, A, De Simone, G. Deposit date: 2026-05-12 Release date: 2026-08-05 Last modified: 2026-09-02 Method: X-RAY DIFFRACTION (1.05 Å) Cite: 1-Aryl-6,7-Dimethoxy-3,4-Dihydroisoquinoline-2(1H)-Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity. Chemmedchem, 21, 2026