Use of Saliva Specimens for Monitoring Indinavir Therapy in Human Immunodeficiency Virus-Infected Patients

Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% ± 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.