Increased lipid peroxidation-derived cyclic DNA adduct γ-OHPdG and mutations in high fat diet-induced hepatocarcinogenesis and its prevention by Theaphenon E

Increased hepatic γ-OHPdG formation in mice fed a high fat diet during early fatty liver disease may be an initiating event for hepatocarcinogenesis through accumulation of mutations and this process can be effectively blocked by Theaphenon E .