Qualitative comparison between multiple models of frequency-specific anaesthesia effect and data obtained in vivo.

In all models, anaesthesia effects were associated with either HF tuned inputs or LF tuned inputs, but never to both. Frequency-specific effects were implemented as a decrease of the cortical input firing rate (“input”) or an increase of presynaptic adaptation (“presyn”), either one of them (1 to 8) or both (9 to 12). In addition, some of the models can include an increment of postsynaptic adaptation (“postsyn”), which is not frequency specific (5 to 8 and 11 to 12).