Gene expression profiling in the seminal vesicles (SVs) from neonatal DES-treated mice [array]. Mus musculus

DES is a synthetic estrogen that is associated with adverse effects on reproductive organs. Our group has employed estrogen receptor (ER) α knockout (αERKO) mice to gain insight into the contribution of ER-dependent pathways in mediating the effects of neonatal DES exposure in female and male reproductive tract tissues. The objective of this study is to compare gene expression profiles between the WT-veh and -DES groups or αERKO-veh and -DES from the adult male mice (week 10) of the SV tissues to identify differential genes. Overall design: Mice were neonatally exposed to DES. RNA was isolated from week 10 SVs and then hybridized on Affymetrix microarray.