GVHD tissue-specific immunogenic CMV peptide matches, CMV reactivation before GVHD patients.

Patient-specific process of cross comparison along with the source genes, IC50 values to indicate inverse binding affinity and GVHD organ specific tissue involvement. *Note: Twelve patients with CMV reactivation/infection before GVHD onset exhibited previously identified immunogenic CMV peptide matches with gene expression specific to the tissues affected by GVHD (above); The filter of immunogenicity provides a connection to T cell reactivity shown in vitro to the listed CMV genes in a separate patient population [36]; Patient 79 with muscle/fascia GVHD showed no muscle-specific previously known immunogenic CMV peptide matches but still had three relevant CMV peptide matches expressed in the skeletal muscle (not shown); Tissues in parentheses were also affected by GVHD but without immunogenic matches/expression by patient; Patients 67 and 71 experienced de novo CMV infection; All 13 patients exhibited multiple CMV peptide matches with unknown immunogenicity.