Cortical organoids in Huntington's disease reveal a chaotic premature corticogenesis cascade and precede HD subcortical projections

Bulk RNA-seq characterization of human cortical organoids derived from two HD patients (CAG55 and 59) and one healthy (CAG19) sibling's induced pluripotent stemm cells (iPSCs) and human embryonic stemm cells H9 . Overall design: Comparative gene expression profiling analysis of RNA-seq data for control group (CAG19 and H9) and HD group (CAG55 and 59)