Optimized alternative ordering of dapagliflozin and sacubitril-valsartan in post-myocardial infarction heart failure

We tested it in an animal model of myocardial infarction to ensure whether early initiation of dapagliflozin (DAPA), or different orders of combination with sacubitril-valsartan would result in a greater improvement of heart function than sacubitril-valsartan alone in post-myocardial infarction heart failure.本研究采用心肌梗死（myocardial infarction）动物模型开展实验，旨在探究早期应用达格列净（dapagliflozin，DAPA），或是其与沙库巴曲缬沙坦（sacubitril-valsartan）的不同联合给药顺序，是否较单独使用沙库巴曲缬沙坦更能改善心肌梗死后心力衰竭的心脏功能。