Antagonizing IL-1β to treat GBM

Monocytes and monocyte-derived macrophages (MDM) from blood circulation infiltrate and promote glioblastoma growth by, at least partially, expressing pro-inflammatory cytokine IL-1β . Using SC-RNA seq, we analyze how IL1a and IL1b differentially contibute to tumor growth. We induced de novo brain tumor in WT, IL1b-KO and IL1ab-KO mice of both genders. We isolated brain tumor cells at the humane endstage of these mice and run sc-RNA seq on these cells to compare their funcitonal differences.