Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1

We used RNA-sequencing to deeply characterize the cellular factors and pathways modulated by CCL2 blocking in MDMs and involved in HIV-1 replication restriction. Gene differential expression analysis was performed and then Functional annotation was done to up-regulated genes Reads that failed mapping to human genome was mapped to HIV-1 reference genome. Note that some samples in this experiment have no raw files as the data has been lost.