PRMT5 Bound to Compound 6 and MTA
收藏Protein Data Bank Japan2026-01-14 更新2026-04-19 收录
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PRMT5 Bound to Compound 6 and MTA Descriptor: 4-amino-1-methyl-N-[(1R)-1-(pyrimidin-2-yl)ethyl]-N-{[5-(trifluoromethyl)pyridin-2-yl]methyl}-1H-pyrazolo[4,3-c]quinoline-8-carboxamide, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... Authors: Ferrao, R. Deposit date: 2025-08-06 Release date: 2026-01-07 Last modified: 2026-01-14 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect. J.Med.Chem., 69, 2026
创建时间：
2025-08-06
