Pharmacokinetic characteristics of <sup>86</sup>Y-CHX-A’’-DTPA panitumumab and <sup>86</sup>Y-CHX-A’’-DTPA-cetuximab.
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Pharmacokinetic characteristics of 86Y-CHX-A’’-DTPA-panitumumab and 86Y-CHX-A’’-DTPA-cetuximab injected i.v. via tail vein of female athymic (NCr) nu/nu mice bearing NCI-H226, MSTO-211H and NCI-H2052 tumor xenografts. Data represent the mean values from three to six determinations. *Receptor blocking studies were performed by co-injecting 0.1 mg mAb with the radiotracer. Values obtained from the blocking studies were significantly lower than the unblocked studies (p<0.05) demonstrating receptor-mediated accumulation in the tumors. #Values obtained from 86Y-CHX-A’’-DTPA-panitumumab and 86Y-CHX-A’’-DTPA-cetuximab were significantly different from each other (p<0.05).
创建时间：
2011-03-25
