RNA-seq in male and female mouse liver for two mouse strains: C57BL/6J and CAST/EiJ.

Sequencing files provided here are mouse liver RNA-seq in two mouse strains: C57BL/6J and CAST/EiJ. This is part of a larger study published in PLoS Genetics (2021) "Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model" that includes DNase-seq and H3K27ac ChIP-seq in mouse liver from the same two strains. This allows us to identify strain-shared ("core") and strain-unique sex-biased genes and enhancers. RNA-seq in male and female mouse liver, n=5 biological replicates per sex and per strain本数据集提供的测序文件为两种小鼠品系（C57BL/6J与CAST/EiJ）的小鼠肝脏RNA测序（RNA-seq）数据。本数据集是2021年发表于《公共科学图书馆·遗传学（PLoS Genetics）》的一项大型研究的一部分，该研究的论文标题为「利用自然变异鉴定多品系小鼠肝脏模型中性别偏倚基因表达的顺式调控因子」，且涵盖了上述两种品系小鼠肝脏的DNase测序（DNase-seq）与H3K27ac染色质免疫共沉淀测序（ChIP-seq）数据。借助该多组学数据集，我们可鉴定品系共享（即「核心」）以及品系特异性的性别偏倚基因与增强子。本次RNA-seq数据覆盖雌雄小鼠肝脏样本，每个品系的每一种性别均设有5次生物学重复。