Tlr9

Predicted to enable several functions, including interleukin-1 receptor binding activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including positive regulation of intestinal epithelial cell development; positive regulation of macromolecule biosynthetic process; and regulation of defense response. Acts upstream of or within several processes, including cellular response to chloroquine; negative regulation of ERK1 and ERK2 cascade; and regulation of dendritic cell cytokine production. Located in cytoplasmic vesicle; endoplasmic reticulum; and plasma membrane. Is expressed in brain and intestine. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Nov 2024]

该基因预测具备多种功能，包括白介素-1受体结合活性、核酸结合活性和蛋白质同源二聚化活性。参与多种生理过程，诸如肠上皮细胞发育的正向调控、大分子生物合成过程正向调控以及防御反应的调控。在多个过程中发挥上游或内部作用，包括细胞对氯喹的反应、ERK1和ERK2级联反应的负向调控以及树突状细胞细胞因子生产的调控。位于细胞质囊泡、内质网和质膜中。在脑部和肠道中表达。用于系统性红斑狼疮的研究。该基因的人源同源基因与多种疾病有关，包括过敏性支气管肺曲霉病、囊性纤维化、肾小球肾炎（多发性）、乙型肝炎以及多发性肺部疾病。与人Toll样受体9（Toll样受体9）同源。[由基因组资源联盟提供，2024年11月]