Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=eb633c5d75b61bd8d05943ca076b7717
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资源简介：
Drug resistance is a central problem in cancer therapy, yet the underlying mechanisms remain obscure. Cancer cells typically acquire resistance via genetic mutations, but may also adopt reversible epigenetic phenotypes that allow them to persist through drug exposure. In glioblastoma, poor efficacy of receptor tyrosine kinase (RTK) therapies has been alternatively ascribed to genetic heterogeneity or to epigenetic transitions that circumvent signaling blockade.
提供机构：
Dana-Farber Cancer Institute
创建时间：
2022-02-20
